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pain in the neck fireman find in many medical specialty cabinet may aid forestall some of the learning and memory problems often receive by people who regularly use aesculapian marijuana , a new subject suggests .
In a serial of experiments done on mouse , researchers discover they could preclude or lessenmarijuana ’s cognitive side effectsby giving the drug ’s active ingredient , a chemical substance called delta-9 - tetrahydrocannabinol ( THC ) , in combination with either Celebrex , a ethical drug pain reliever , or ibuprofen , an over - the - parry nonsteroidal anti - inflammatory drug ( NSAID ) .
" Our determination suggest that the unwanted side effects of marihuana could be eliminated or thin , while its beneficial upshot can be retained , " said study investigator Chu Chen , a prof of neuroscience at Louisiana State University Health Sciences Center in New Orleans . [ Trippy Tales : The History of 8 Hallucinogens ]
Chen said his team is planning to proceed their research in humans in the close future , to see if the findings declare unfeigned .
The findings were put out online today ( Nov. 21 ) in the journal Cell .
Preventing side impression
Marijuanahas been used as a medical intervention for a few thousand years , Chen enounce . The drug has been used to still symptoms for everything from inveterate pain and multiple induration to cancer and capture disorders .
However , theunwanted effects of cannabisgreatly limit its medical exercise , Chen told LiveScience . So his enquiry team set out to understand the molecular mechanisms underlie these adverse effects .
The researcher found that mice treat with THC had an increase in levels of a chemical called cyclooxygenase-2 ( COX-2 ) in the hippocampus , a partof the brain involved in memory and learning .
" We uncovered the brain-teaser of the marijuana - induce contrary force , and its signaling pathway , " Chen said .
This led the research worker to quiz the effects of giving the mice drug that blue COX-2 level , admit Celebrex and ibuprofen .
The findings suggest that give people a COX-2 inhibitor drug along with medical ganja may help oneself to reduce the memory and learning problems connect with its retentive - term treatment , the investigator say .
But further testing is want in human clinical trials . At this point , it ’s still too early to determine the dose or frequence of Celebrex or Advil that could be open to foreclose marijuana - stimulate side effects , or to say when the pain relievers should be taken , Chen say .
Broader medical consumption
Marinol is the brand name of the prescription marijuana medication currently approved in the United Statesto address the nausea and disgorgement because of chemotherapy .
But some the great unwashed are put off by the memory board release , discombobulation and sleepiness that can come with on a regular basis taking Marinol , which greatly limits its use .
Based on the new findings , investigator may be capable to broaden themedical use of marijuanaby reduce its undesirable effects while retaining its good property , Chen said .
Chen said he mistrust his determination can be hold to both Marinol and the smokable course of aesculapian marijuana , which is now sound in some states . But he cautioned that smoke pot may also impress the lung , a reason why some pharmaceutical manufacturers have developed a spray mannikin of ganja that is spritzed into the rima oris .
When asked whether these determination might apply to mass who fume pot recreationally , Chen said it depends on how much marijuana they use .
" The memory impairments take place only in people who use marijuana heavily , " he said .
